Andexxa drug4/3/2023 ![]() ![]() The active ingredient of ANDEXXA is a genetically modified variant of human Coagulation Factor Xa. You may report side effects to FDA at 1-80. The proprietary name is Andexxa and the International Nonproprietary Name is andexanet alfa. It is marketed as Andexxa for intravenous injection or infusion and is indicated for the reversal of anticoagulation in combination with rivaroxaban and apixaban in cases of life-threatening or uncontrolled bleeding. Call your doctor for medical advice about side effects. It was developed by Portola Pharmaceuticals and was approved in in May 2018. This is not a complete list of side effects and others may occur. The half-life of apixaban is even longer, 12 hours. On the other hand, the half life of rivaroxaban is 10+ hours in the elderly. The reversal effect of Andexxa begins to wear off two hours after administration, and is gone by four hours. pain, swelling, burning, or irritation around the IV needle. The half-life of Andexxa is much shorter than that of the drugs it reverses.It's typically given in the hospital or urgent care setting by a trained healthcare provider through your vein. Prior Approval Supplement for Andexxa Generation 2 Manufacturing. Andexxa (andexanet alfa) is an injectable medication used to treat life-threatening or uncontrolled bleeding in people taking anticoagulants (blood thinners) called Xarelto (rivaroxaban) or Eliquis (apixaban). heart attack symptoms-chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating.Ĭommon side effects of coagulation factor Xa may include: Food and Drug Administration Approves Portola Pharmaceuticals.signs of a blood clot-sudden numbness or weakness, problems with vision or speech, swelling or redness in an arm or leg or.Get emergency medical help if you have any of these symptoms after being treated with coagulation factor Xa, especially if you have not started taking anticoagulant medication again: Reversing the effects of anticoagulant medication may increase your risk of a blood clot, heart attack, stroke, or death. cough with mucus, chest pain, and shortness of breath.Get emergency medical help if you have signs of an allergic reaction: hives difficult breathing swelling of your face, lips, tongue, or throat. Side Effects What are the side effects of Andexxa (Coagulation Factor Xa)? ![]()
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